"Roseanne" is returning to ABC at the end of March.
In its first nine seasons, the outspoken matriarch of the Conner clan rubbed elbows with the likes of George Clooney and Bruce Willis all while tackling unemployment and pinching pennies to raise her dysfunctional middle-class family.
The list of celebrity guest stars goes all the way to the show's first season in 1988. While some of them were big names in their own right playing themselves, some celebrities appeared on the show before they were big like Leonardo DiCaprio and Joseph Gordon-Levitt.
Even a few stars from ABC hit "Grey's Anatomy" appeared alongside the Conners.
Before the show's season 10 premiere, take a look back at the famous faces who have shown up in Lanford, Illinois.
Leonardo DiCaprio was one of Darlene's classmates in a home economics class.
When Roseanne went to Darlene's class to talk about being a homemaker, DiCaprio could be seen sitting next to Darlene.
Joseph Gordon-Levitt played a new friend of DJ's who liked to ramble.
George was the new kid at school on season five who DJ and the rest of his family got easily annoyed with.
George Clooney was Jackie and Roseanne's original boss, Booker Brooks, at Wellman Plastics.
Brooks started dating Jackie and failed at keeping it a secret.
His last appearance was on season four during a Halloween episode where he dressed up as a moose.
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